Foundation Models

7 articles


AlphaFold 3IsoDDEProtein-ligand prediction2× more accurateAntibody-antigen structures2.3× vs AF3, 19.8× vs BoltzNovel binding pocketsfrom sequence aloneBinding affinitybeats FEP at fraction of costIsomorphic Labs · February 2026
Structure Prediction

Isomorphic Labs Unveils IsoDDE Drug Design Engine, Doubling AlphaFold 3's Accuracy in Protein-Ligand Prediction

Isomorphic Labs unveiled IsoDDE, an AI drug design engine that more than doubles AlphaFold 3's accuracy in protein-ligand prediction and identifies novel binding pockets from sequence alone, as the company prepares for its first clinical trials.

·2 min
OPEN SOURCE1,000,000base pairs · single-nucleotide resolution3,000scientists using it160countries25/26benchmarks won
Foundation Models

Google DeepMind Open-Sources AlphaGenome, an AI Model That Predicts DNA Function Across 1 Million Base Pairs

Google DeepMind open-sourced AlphaGenome, an AI model published in Nature that predicts DNA function across 1 million base pairs, already used by nearly 3,000 scientists worldwide for cancer and disease research.

·2 min
SERIES A$150M$850M valuationCo-founded by Eric SchmidtSpun out of UCL + King's College London$200M upfront to MeiraGTx for Parkinson's gene therapyDrug development + diagnostics + investment in one entity
Platform

Hologen, AI Biotech Co-Founded by Eric Schmidt, Raises $150M Series A at $850M Valuation

Hologen, co-founded by former Google CEO Eric Schmidt, is raising $150M at an $850M valuation, combining AI drug development with a $430M MeiraGTx gene therapy partnership for Parkinson's disease.

·2 min
CHAI DISCOVERY · SERIES B$1.3Bvaluation · $130M raisedChai-2: de novo antibody design100×vs previous methods16%zero-shot hit rate86%drug-like profilesBacked by OpenAI, Thrive, General Catalyst
Antibody Design

Chai Discovery Raises $130M Series B at $1.3B Valuation, Unveils Chai-2 for Zero-Shot Antibody Design

Chai Discovery raised $130M at a $1.3B valuation in December 2025, backed by OpenAI and others, after unveiling Chai-2 with a 100x improvement in zero-shot de novo antibody design and a 16% hit rate.

·2 min
The Evolution of AI in Scientific Discovery: A New Era in the Life Sciences
Protein Structure Prediction

The Evolution of AI in Scientific Discovery: A New Era in the Life Sciences

Intro AI has rapidly evolved from science fiction into a practical tool accelerating real scientific breakthroughs. In laboratories and research centers around the world, AI systems are crunching data, designing experiments, and even formulating...

·23 min
The Protein Language Model: Bigger = Better?
Protein Structure Prediction

The Protein Language Model: Bigger = Better?

Exhibit A Profluent has announced their new family of foundation models for protein generation, the ProGen3 series. Whether you’re looking to understand their methods and findings, or simply curious on what the heck a protein language model is ––...

·15 min
AI is becoming the lab. Expert insights from NVIDIA GTC 2025, Foundation Models for Drug Discovery, etc.
Protein Structure Prediction

AI is becoming the lab. Expert insights from NVIDIA GTC 2025, Foundation Models for Drug Discovery, etc.

Sprintome is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. From foundation models like Evo 2 and Alphafold 3 to synthetic data generation and agentic AI workflows — Next‑gen AI...

·7 min

Stay current

Weekly digest of AI drug discovery developments. No noise.