Generative Chemistry

10 articles


FIRSTAI-designed drug enters human trialsAI DESIGNPRECLINICALPHASE IIsomorphic LabsBuilt on AlphaFold + IsoDDE$3BLilly + Novartis partnerships
Clinical Trials

DeepMind CEO Confirms First AI-Designed Cancer Drug Entering Phase 1 Clinical Trials in 2026

Demis Hassabis confirmed that Isomorphic Labs' first AI-designed cancer drug will enter Phase 1 clinical trials in 2026, built on the AlphaFold-derived IsoDDE platform and backed by $3 billion in Lilly and Novartis partnerships.

·2 min
FAMOUS LABSHeisenbergQuantum-informed molecule prioritizationelectron densityclosed-loop AIsynth feasibilityEvery molecule comes with a hypothesis
Virtual Screening

Famous Labs Launches Heisenberg, a Quantum-Informed AI System for Small Molecule Drug Discovery

Famous Labs launched Heisenberg, a quantum-informed AI platform that integrates electron-density molecular representations with ADMET and synthesis data to optimize molecule prioritization in drug discovery.

·2 min
AlphaFold 3IsoDDEProtein-ligand prediction2× more accurateAntibody-antigen structures2.3× vs AF3, 19.8× vs BoltzNovel binding pocketsfrom sequence aloneBinding affinitybeats FEP at fraction of costIsomorphic Labs · February 2026
Structure Prediction

Isomorphic Labs Unveils IsoDDE Drug Design Engine, Doubling AlphaFold 3's Accuracy in Protein-Ligand Prediction

Isomorphic Labs unveiled IsoDDE, an AI drug design engine that more than doubles AlphaFold 3's accuracy in protein-ligand prediction and identifies novel binding pockets from sequence alone, as the company prepares for its first clinical trials.

·2 min
NVIDIA×Eli Lilly$1B5-year AI co-innovation lab · South San FranciscoBioNeMo + Blackwell DGX SuperPOD · scientist-in-the-loop
Platform

NVIDIA and Eli Lilly Announce $1 Billion AI Co-Innovation Lab to Reinvent Drug Discovery

NVIDIA and Eli Lilly announced a $1 billion AI co-innovation lab in South San Francisco, combining Lilly's pharmaceutical expertise with NVIDIA's BioNeMo platform and Blackwell-powered supercomputing to reinvent drug discovery.

·2 min
INSILICO MEDICINE · JAN 2026$888MOncology deal with Servier$292M IPOHong Kong Stock Exchange · largest biotech IPO of 2025+45%day one15 cornerstone investors incl. Eli Lilly, Tencent, TemasekFirst AI-discovered drug (rentosertib) positive Phase 2a
Target Discovery

Insilico Medicine Strikes $888M Oncology Deal with Servier Days After Hong Kong IPO

Insilico Medicine announced an $888M oncology partnership with Servier days after raising $292M in the largest Hong Kong biotech IPO of 2025, with shares surging 45% on debut.

·2 min
Nature MethodsBaker Lab · U. of WashingtonDesigning functional enzymes from scratch41/41active sites scaffolded (vs 16 with previous methods)53kM⁻¹s⁻¹ catalytic efficiencyApproaches natural enzyme activity levelsRFdiffusion3 also released: 10× faster, open sourceJanuary 2026
Structure Prediction

RFdiffusion2 Designs Functional Enzymes from Scratch, Published in Nature Methods

David Baker's lab published RFdiffusion2 in Nature Methods, demonstrating an AI model that designs functional enzymes from scratch with catalytic activities approaching natural enzymes, alongside the open-source release of the faster RFdiffusion3.

·2 min
Target to preclinical candidateTRADITIONAL2.5 — 4 yearsINSILICO AI8 monthstime savedInsilico Medicine × Hisun PharmaceuticalPandaOmics + Chemistry42 + inClinico
Target Discovery

Insilico Medicine and Hisun Pharma Nominate Preclinical Candidate in Just 8 Months Using AI

Insilico Medicine and Hisun Pharma nominated a preclinical candidate in just 8 months using the Pharma.AI platform, dramatically compressing a process that typically takes 2.5 to 4 years in traditional drug discovery.

·2 min
CHAI DISCOVERY · SERIES B$1.3Bvaluation · $130M raisedChai-2: de novo antibody design100×vs previous methods16%zero-shot hit rate86%drug-like profilesBacked by OpenAI, Thrive, General Catalyst
Antibody Design

Chai Discovery Raises $130M Series B at $1.3B Valuation, Unveils Chai-2 for Zero-Shot Antibody Design

Chai Discovery raised $130M at a $1.3B valuation in December 2025, backed by OpenAI and others, after unveiling Chai-2 with a 100x improvement in zero-shot de novo antibody design and a 16% hit rate.

·2 min
The Evolution of AI in Scientific Discovery: A New Era in the Life Sciences
Protein Structure Prediction

The Evolution of AI in Scientific Discovery: A New Era in the Life Sciences

Intro AI has rapidly evolved from science fiction into a practical tool accelerating real scientific breakthroughs. In laboratories and research centers around the world, AI systems are crunching data, designing experiments, and even formulating...

·23 min
AI is becoming the lab. Expert insights from NVIDIA GTC 2025, Foundation Models for Drug Discovery, etc.
Protein Structure Prediction

AI is becoming the lab. Expert insights from NVIDIA GTC 2025, Foundation Models for Drug Discovery, etc.

Sprintome is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. From foundation models like Evo 2 and Alphafold 3 to synthetic data generation and agentic AI workflows — Next‑gen AI...

·7 min

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