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Generate:Biomedicines

Generative AI for de novo protein therapeutic design

Founded2020
HQCambridge, MA
StagePreclinical
Total Funding$700M+
generatebiomedicines.com
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Overview

Generate:Biomedicines applies generative AI and machine learning to design novel protein therapeutics from scratch. The company's platform, anchored by the Chroma generative model for protein structure, integrates computational design with high-throughput experimental validation. Backed by Flagship Pioneering with approximately $700M in total funding, Generate has established a major partnership with Novartis worth over $1B in potential milestones and is advancing approximately 20 programs across its portfolio.

Focus areas

Generative Chemistry, Antibody Design, Foundation Models

Key models

Chroma

~20 programs in portfolio


Funding

$700M+

Total raised

Series C2023

$273M

Led by Flagship Pioneering

Series AFlagship Pioneering
$50M2020
Series BFlagship Pioneering
$370M2021
Series CFlagship Pioneering
$273M2023
Notable investors

Flagship Pioneering · Amgen · NVIDIA


Technology

Generative AI platform for de novo protein therapeutic design. Chroma is a generative model for protein structure that can design entirely new proteins with specified properties. The platform integrates ML-based design with high-throughput experimental validation across antibodies and other protein modalities.

Platforms & Tools
ChromaThe Generate PlatformHigh-throughput protein characterization
Notable Publications
  • Illuminating protein space with a programmable generative model (Nature, 2023)

Leadership

Mike Nally

CEO

Former McKinsey healthcare practice leader


Partnerships
NovartisMulti-target collaboration to discover and develop protein therapeutics with generative AI
$1B+2024

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