Boltz PBC

Boltz is a public benefit corporation spun out of MIT CSAIL that builds open-source biomolecular AI foundation models. Their flagship model Boltz-1 achieves AlphaFold 3-level accuracy in predicting 3D structures of protein-ligand complexes while being fully open source. Boltz-2 adds binding affinity prediction at 1000x the speed of physics-based free energy perturbation methods. Used by over 100,000 scientists globally, Boltz also offers Boltz Lab, a commercial platform for drug discovery teams.

$28M

Total raised

Open-source biomolecular structure prediction models. Boltz-1 predicts 3D structures of protein-ligand, protein-protein, and protein-nucleic acid complexes with state-of-the-art accuracy. Boltz-2 extends this with binding affinity prediction, achieving performance comparable to physics-based FEP methods at 1000x the speed.