EvolutionaryScale

EvolutionaryScale is a frontier AI research lab for biology, building large-scale foundation models for understanding and generating proteins. Its flagship model ESM3 was trained on 2.78 billion proteins with more compute than any known model in biology. ESM3 demonstrated the ability to generate a novel Green Fluorescent Protein — a feat the company says would take 500 million years of natural evolution. Founded by the ex-Meta AI team behind the ESM protein language model series.

$142M+

Total raised

ESM3 is a 98 billion parameter protein language model trained on the sequences, structures, and functions of 2.78 billion proteins. It can simultaneously reason across protein sequence, structure, and function, and has demonstrated the ability to generate entirely novel functional proteins including a GFP with only 58% sequence identity to known fluorescent proteins.